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Pregnenolone is a precursor for all other steroid hormones naturally present in the body. It is converted directly into DHEA, which in turn converts to testosterone, estrogens, cortisol and aldosterone. It is this same set of successive conversions that makes human life possible. Without the presence of Pregnenolone, there can be no human steroid production. Research into Pregnenolone with factory workers and pilots began in the 1940's, and the evidence rapidly materialized that Pregnenoline had energizing and cumulative anti-stress, anti-fatigue and anti-depression effects, especially after it was taken after a period of two weeks. Studies at St. Louis School of Medicine showed the memory enhancement effects of pregnenolone, with improvement in spatial memory, perception and verbal recall.
There is considerable evidence that pregnenolone modulates both NMDA and GABA receptors systems in the brain (which are involved in learning, memory and alertness and decrease with age). Pregnenoline enhances NMDA receptor function and lowers excessive GABA activity and seems to be a natural anti-depressant. During research conducted in the 1940's, it was found pregnenolone use resulted in a reduction in joint pain - it was used as a treatment for arthritis, but it was replaced by Cortisone in the 1950's. The body produces a steroid called cortisol, the levels of which increase with age, causing a number of problems.
Pregnenolone counteracts the negative effects of accumulating cortisol levels in the body, including the enhancement of memory areas in the brain damaged by cortisol. One of the major determinants of the body's ability to detoxify poisonous chemicals is the health and effectiveness of the Cytochrome P450 enzyme system in the liver. Pregnenolone increases the overall P450 detox enzyme power of the liver by promoting conservation of the existing enzymes, promoting body detoxification processes.